Could Omeprazole damage the kidney?
Many factors may contribute to the development of kidney disease, and new findings has been linked some of those caused by a certain pharmaceuticals, including proton pump inhibitors drugs. Proton pump inhibitors (PPIs) such as Prevacid, Prilosec (omeprazole) and Nexium have been associated with renal failure. Numerous studies suggested that these drugs may cause kidney disease. Dr. Cynthia A. Naughton of the North Dakota State University College of Pharmacy said that PPIs cause 20 % of acute kidney injury. However, researchers are still seeking for exact mechanism and to explain the reason why, but one theory is that PPIs may cause kidney injury by lowering levels of magnesium, that is crucial to proper kidney function. Interstitial nephritis has been most commonly assocoiated to PPI usage. A 2015 study published by the Pharmaceutical Journal stated, “All PPIs are associated with acute interstitial nephritis.” Older study from 2013 published by BMC Nephrology, looked at 184,480 patients on PPIs therapy and also found a positive link between renal disease and PPI usage, even after adjusting for other possible contributing factors. Further studies into PPIs’ impact on the kidneys are in progress.
In early 2016, a significant number of researches has been published and linked PPI use to kidney disease. In April, researchers at the Veterans Affairs St. Louis Health Care System released a report showing that PPIs patients were more likely than those who used alternative heartburn drugs such as antacids and H2-antagonist to have CKD or ESRD within five years from the start of PPI usage. In January, a study published in the JAMA Network Journals stated that PPI users had a 15.9 percent risk of developing kidney disease over 10 years, whereas non-PPI users only had a 13.9 percent risk. Several academic and medical institutions are currently performing deeper research into this link.