How fast does Omeprazole works?
After taking Omeprazole, the reduction of acid production in the stomach occurs within an hour, with the maximum effect occurring within two hours. Omeprazole reduces the stomach acid-production about 50% during the first 24 hours. Antiacid effect lasts up to 72 hours.
With daily use of Omeprazole, the antacid effect increases until it reaches a plateau after 4 days. Increasing dosage after plateau has virtually no effect, but increasing dose frequency to morning and evening dose before meals may maximize blockage of acid production in the stomach.
When Omeprazole is discontinued, the production of acid by the stomach returns to normal over 3 to 5 days.