Clopidrogrel requires activation by CYP 2C19 to work as a platelet inhibitor. For that reason, it is not recommended the use of Clopidogrel and Omeprazole (at doses 80 mg daily or higher) at the same time. Very recently, spaced administration of a clopidogrel and 40 mg immediate-release omeprazole was considered as an alternative that might reduce the potential interaction between omeprazole and clopidogrel.
When a patient taking Methotrexate start on Omeprazole, it requires monitoring of Methotrexate levels. Omeprazole reduces the elimination of Methotrexate from our body, and accumulation of Methotrexate can reach toxic levels. Methotrexate prescribed one dose weekly may not need monitoring. In other cases, when patient need high levels of Methotrexate for a short period of time, prescriber may recommend to stop taking Omeprazole temporarily.
Warfarin and Omeprazole can be used together, however, it requires monitoring of INR after a week of starting and stopping Omeprazole, and adjust dose of Warfarin accordingly. It is a fact that Omeprazole Can Increase INR and prothrombin time. Dismissing motoring and subsequent
adjust in dose, Can Increase chances of a patient to experience abnormal bleeding with serious complications.
How our body eliminates Omeprazole?
Omeprazole gets completely eliminated from our blood between doses: 80 % get eliminated through the urine, and 20% is eliminated through the feces.
Omeprazole is well tolerated by seniors and patient with liver issues at the 20 mg dose. Patients with kidney issues do not require any adjustment in their dose of Omeprazole.
How fast does Omeprazole works?
After taking Omeprazole, the reduction of acid production in the stomach occurs within an hour, with the maximum effect occurring within two hours. Omeprazole reduces the stomach acid-production about 50% during the first 24 hours. Antiacid effect lasts up to 72 hours.
With daily use of Omeprazole, the antacid effect increases until it reaches a plateau after 4 days. Increasing dosage after plateau has virtually no effect, but increasing dose frequency to morning and evening dose before meals may maximize blockage of acid production in the stomach.
When Omeprazole is discontinued, the production of acid by the stomach returns to normal over 3 to 5 days.
- Take Omeprazole 30 minutes before meals.
- Antacids may be used concomitantly with Omeprazole.
- Swallow Omeprazole as a whole; do not chew.
- For patients unable to swallow an intact capsule, Omeprazole delayedrelease capsules can be opened and administered in applesauce.
- Omeprazole for delayed-release oral suspension is intended to be prepared in water and administered orally or via a nasogastric (NG) or gastric tube.!
- Must follow pharmacist and/or doctor’s instructions exactly.
Overdose of Omeprazole and how to treat it
Overdose of Omeprazole can cause:
- blurred vision,
- fast heart beat,
- dry mouth,
- and other adverse reactions similar to those seen at normal doses of Omeprazole. Symptoms are transient, and no serious clinical outcome has been reported when an overdose of Omeprazole was taken alone.
No specific antidote for omeprazole overdosage is known. Omeprazole is extensively protein bound and is, therefore, not readily dialyzable. In the event of over dosage, treatment should be symptomatic and supportive.