Can I take omeprazole with methotrexate

When a patient taking Methotrexate start on Omeprazole, it requires monitoring of Methotrexate levels. Omeprazole reduces the elimination of Methotrexate from our body, and accumulation of Methotrexate can reach toxic levels. Methotrexate prescribed one dose weekly may not need monitoring. In other cases, when patient need high levels of Methotrexate for a short period of time, prescriber may recommend to stop taking Omeprazole temporarily. 

Interaction of Clopidogrel and Omeprazole