Lamotrigine and Omeprazole interaction
Omeprazole may increase serum levels the pharmacologic effects and of certain benzodiazepines including clonazepam which is an active ingredient of Lamictal, through hepatic enzyme inhibition. Patient should be monitored closely for increased sedation, breathing problems and drowsiness. Reduced benzodiazepine dosage may be indicated, especially in elderly. Benzodiazepines which are not metabolized through oxidation such as lorazepam, oxazepam and temazepam are not expected to interact with omeprazole and may be considered as safe alternatives.