Do omeprazole stop iron intake?
Omeprazole controls the acidity in the stomach regularly. The low acidity could reduce the absorption of some medications: iron salts, erlotinib, dasatinib, mycophenolate mofetil, ketoconazole/itraconazole
– Non-heme Iron salts(ferrous fumarrate, ferrous sulfate, ferrous gluconate) need acidity in the stomach for absorption. Omeprazole reduces acidity in the stomach to the point, absorption of some iron salts can be affected.
Omeprazole and Iron supplements
Your prescriber needs to know you are taking Omeprazole, at the time you get prescribed Iron supplements. A few iron supplements are not affected by the low acidity in the stomach. Other strategies could be for patients on Omeprazole and iron supplements may have to be treated either with high dose iron therapy for a longer duration or with intravenous iron therapy.
“Can I take omeprazole with Voriconazole?“
Omeprazole oral and Voriconazole oral Drug Interactions
Voriconazole gets metabolized by CYP 2C19. That’s why patient on Omeprazole will get increased blood levels of Voriconazole than patients without Omeprazole. Dose adjustments are required when patient is taking Omeprazole to control Zollinger-Ellison syndrome or in any case patient is taking more than 40 mg per day. While treating someone with Voriconazole, keep Omeprazole at 20 mg daily, or lower.
“Can I take Omeprazole with Carbamazepine(Tegretol)?“
Omeprazole and Tegretol Drug Interactions
More Carbamazepine than in average patients, reaches our blood when taking Omeprazole. Omeprazole slows down the elimination of Carbamazepine, as well. Furthermore, Omeprazole’s effectiveness is
decreased by the combination with Carbamazepine. When patient is taking Omeprazole and Carbamazepine together, it is recommended to monitor Carbamazepine levels in blood. It is also advisable to consider other PPIs for patients on Carbamazepine.
“Can I take omeprazole with Digoxin?“
Digoxin effects get increased by the use of Omeprazole. Omeprazole seems to increase the absorption of digoxin and as a consequence, digoxin could reach toxic levels. Digoxin intoxication Can Include: nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat. Doctor needs to monitor and adjust the dose of both medications.
“Can I take omeprazole with diazepam?“
Diazepam and Omeprazole interaction
Diazepam’s elimination slows down considerably when taking Omeprazole. Which increases the risk of side effects of Diazepam including excessive drowsiness, confusion and breathing difficulties. Patient may need a dose reduction of both medications and/or more frequent monitoring while using Omeprazole and Diazepam at the same time.
“Omeprazole interactions with Rilpivirine, Indinavir, Atazanavir and Nelfinavir“
Interactions that have clinical influences
Omeprazole is one of those drugs that is well known in the field of drug-drug interactions. The fact that Omeprazole reduces the activity of liver enzyme CYP 3C19, can modify the transit of several drugs through the liver when taking Omeprazole.
Each drug interaction requires individual considerations. In some cases, you cannot administer the drugs together so you have to choose which one you should substitute. In other situations you need to take them hours apart. Or while taking them together, you need to adjust the dose of one of the medications.
The important message is: whenever you take 2 or more medications, including non-prescriptions, herbals and vitamins, ask a doctor or a pharmacist to check for possible drug-drug interactions.
Omeprazole interactions with Rilpivirine, Indinavir, Atazanavir Saquinavir and Nelfinavir
Some antiretrovirals get reduced their effectiveness when used with Omeprazole. They are rilpivirine, indinavir, atazanavir and nelfinavir. Omeprazole reduces their antiviral effect and increases the chance of the virus to develop drug resistance to these antivirals. For those reasons, it is contraindicated to give Rilpivirine and Omeprazole together. Specialists
recommend to avoid combination of Indinavir, Atazanavir, or Nelfinavir, with Omeprazole.
- Rilpivirine get a significant reduction in absorption when patient is taking Omeprazole.
- Reduction in solubility and absorption of indinavir, is due to Omeprazoleinduced lower acidity in the stomach. It is not advisable to prescribe indinavir
and Omeprazole together, unless patient is taking Ritonavir as well.
- Atazanavir sees effectiveness reduced by 75% with Omeprazole. A combo atazanavir/ritonavir can reduce the effect of Omeprazole.
- Solubility of Nelfinavir is lesser than in patients without reduced acidity in stomach due to Omeprazole. Omeprazole reduces metabolic activation of Nelfinavir by CYP 2C19 enzyme, as well.
Other antivirals, like saquinavir, could reach toxic levels, when patient is taking Omeprazole at the same time. Anyone taking these combination of antiviral and antacid have to be monitored for potential toxicity.
Omeprazole and Tarceva Drug Interactions
Erlotinib and dasatinib have a substantially reduced absorption in patients taking Omeprazole. While on erlotinib or dasatinib do not start taking any antacid including Omeprazole.
Use of Omeprazole in pregnancy
Studies are not conclusive about consistent use of Omeprazole during pregnancy and which kind of harm could cause to the fetuses/babies. Several studies have reported no apparent short-term effects on an infant when mother got exposed to a single dose of Omeprazole during pregnancy.
In the absence of more results, it is not advisable to recommend consistent use of Omeprazole during pregnancy.
Can I take omeprazole when breastfeeding?
Use of Omeprazole during lactation varies. Omeprazole could be present in human milk. There is no information on the effects of omeprazole on the breastfed infant or effect on milk production. If a breastfeeding mother needs Omeprazole, a prescriber must assess the case.
“How long before Omeprazole is out of my system?“
“Phenytoin and Omeprazole drug interactions“
Phenytoin can reach toxic levels while using Omeprazole. Omeprazole blocks the liver enzyme CYP 2C19, which slows down the elimination of Phenytoin. Toxic levels of phenytoin can cause drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia. When a patient starts(or stops) on Omeprazole, it requires monitoring and possible adjustments in the dose of Phenytoin.
Cilostazol metabolism get altered in different ways by the presence of Omeprazole. This interaction is well studied and documented, and the recommendation is taking Cilostazol 50 mg twice daily while on Omeprazole.
“Drug interactions with omeprazole oral and phenytoin oral“
Citalopram is an antidepressant that get eliminated primarily by the liver. When inhibition of CYP 2C19 for Omeprazole, citalopram can accumulate in our body. Accumulation of citalopram can make our heart work harder(due to QT prolongation). Since it not routine monitoring Citalopram blood levels or QT prolongation effects, patients taking Omeprazole can only take Citaloram up to 20 mg daily.
“Omeprazole and Pletal Drug Interactions“